STREAM is the first large-scale, multi-country clinical trial to investigate shortened regimens for multidrugresistant tuberculosis (MDR-TB), and the first phase III trial to test the efficacy and safety of Bedaquiline, a new drug with a novel mechanism of action, within a shortened treatment regimen.
The trial established a Community Engagement (CE) Plan. The CE program was implemented at thirteen research sites within the STREAM trial, in seven countries. This paper sets out a summary of the experiences of CABs in connection with the STREAM clinical trial. It underlines relevant aspects that may be useful when planning and/or engaging communities in research. In conclusion, the experiences gained during STREAM, lead to both growing confidence in CE as a valuable process and community participation in advocacy.
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