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Inspire: Health Advocates for Clean Air is a collaboration incubated by the global health organization Vital Strategies. The initiative was launched by members of the working group on air pollution and lung health at theInternational Union Against Tuberculosis and Lung Disease. We aim to mobilize a global coalition of clinicians, public health professionals and organizations to advocate for clean, healthy air. By engaging the world’s health community to address the adverse effects of unhealthy air, Inspire aligns with the World Health Organization’s road map for enhanced global action on air pollution.