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Implementation challenges and lessons learned from the STREAM clinical trial—a survey of trial sites

Design and implementation of multi-country clinical trials for multidrug-resistant tuberculosis (MDR-TB) are complex for several reasons, including trial duration, varying levels of experience and infrastructure across settings, and different regulatory requirements. STREAM was an MDR-TB clinical trial that recruited over 1,000 participants. Based on surveys of trial staff in all of the trial’s sites, this study documented challenges and best practices/lessons learned from the site perspective to improve the implementation of future trials.

Published January 23, 2023

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